Macrocyclization of bis-indole quinolines for selective stabilization of G-quadruplex DNA structures
نویسندگان
چکیده
منابع مشابه
G-quadruplex recognition by bis-indole carboxamides.
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
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Quantitative visualization of DNA G-quadruplex structures in human cells.
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Thank you again for submitting your manuscript EMBOJ-2014-88663, "FANCJ promotes replication of G-quadruplex DNA structures." We have now received all the reports from three experts, which I am enclosing copied below. As you will see, the reviewers express some interest in the basic finding of your study, yet they also raise a number of substantive concerns, and issues with the potential to con...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2020
ISSN: 2041-6520,2041-6539
DOI: 10.1039/d0sc03519j